Table 3 Fold change analysis reveals elevated levels of acylcarnitine species in mutant IDH chondrosarcomas
From: Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
| Lipid profiling acylcarnitines | Acylcarnitine length | Fold change—mutant IDH1 vs non-mutant Chondrosarcoma | p-value | Fold change—mutant IDH2 vs non-mutant Chondrosarcoma | p-value |
|---|---|---|---|---|---|
| Acetyl-CoA derivative | |||||
| C2 | SC-AC | 3.0 | 0.0510 | 2.8 | 0.1189 |
| Amino acid derivatives—odd chain species | |||||
| C3 | SC-AC | 2.0 | 0.0430* | 2.6 | 0.2937 |
| C5:1 | SC-AC | 3.0 | 0.3391 | 4.9 | 0.0087* |
| C5 | SC-AC | 4.3 | 0.1445 | 6.3 | 0.3449 |
| C5-OH/C3-DC | SC-AC | 6.2 | 0.2576 | 4.0 | 0.1920 |
| C5-DC | MC-AC | 0.9 | 0.7707 | 1.3 | 0.4642 |
| C7-DC | MC-AC | 3.7 | 0.1326 | 1.7 | 0.5192 |
| Fatty acid derivatives—even chain species | |||||
| C6 | SC-AC | 2.0 | 0.0842 | 2.2 | 0.2127 |
| C8:1 | SC-AC | 0.7 | 0.3901 | 1.2 | 0.7380 |
| C8 | MC-AC | 1.7 | 0.0722 | 1.9 | 0.2351 |
| C8:1-OH/C6:1-DC | MC-AC | 0.9 | 0.7353 | 1.1 | 0.7281 |
| C6-DC/C8-OH | MC-AC | 2.0 | 0.1644 | 2.8 | 0.0969 |
| C10:3 | MC-AC | 1.0 | 0.9255 | 1.1 | 0.8489 |
| C10:2 | MC-AC | 1.1 | 0.8987 | 1.6 | 0.4553 |
| C10:1 | MC-AC | 1.3 | 0.4115 | 0.9 | 0.7575 |
| C10 | MC-AC | 2.9 | 0.0162* | 2.0 | 0.2869 |
| C8:1-DC | MC-AC | 1.6 | 0.5332 | 0.7 | 0.7576 |
| C10-OH/C8-DC | MC-AC | 0.8 | 0.6839 | 0.6 | 0.2910 |
| C12:1 | MC-AC | 1.9 | 0.4518 | 2.2 | 0.0732 |
| C12 | MC-AC | 1.6 | 0.2373 | 1.3 | 0.7066 |
| C12-OH/C10-DC | MC-AC | 0.6 | 0.3945 | 0.9 | 0.8496 |
| C14:2 | LC-AC | 1.1 | 0.7881 | 1.0 | 0.9626 |
| C14:1 | LC-AC | 1.9 | 0.0985 | 1.7 | 0.5002 |
| C14 | LC-AC | 1.8 | 0.1588 | 2.2 | 0.3238 |
| C14:1-OH | LC-AC | 2.1 | 0.2333 | 2.3 | 0.2990 |
| C14-OH/C12-DC | LC-AC | 1.1 | 0.7262 | 0.8 | 0.6335 |
| C16:2 | LC-AC | 1.2 | 0.6409 | 1.2 | 0.7771 |
| C16:1 | LC-AC | 3.1 | 0.0675 | 2.6 | 0.3013 |
| C16 | LC-AC | 3.3 | 0.0164* | 4.1 | 0.2330 |
| C16:1-OH/C14:1-DC | LC-AC | 2.6 | 0.0313* | 4.5 | 0.3420 |
| C16-OH/C14-DC | LC-AC | 1.4 | 0.5234 | 1.8 | 0.3100 |
| C18:2 | LC-AC | 2.4 | 0.2108 | 3.3 | 0.3426 |
| C18:1 | LC-AC | 3.3 | 0.0734 | 2.9 | 0.3638 |
| C18 | LC-AC | 4.8 | 0.1059 | 6.0 | 0.3753 |
| C18:2-OH | LC-AC | 1.3 | 0.4134 | 1.6 | 0.6317 |
| C18:1-OH/C16:1-DC | LC-AC | 2.0 | 0.1328 | 3.6 | 0.3811 |
| C18-OH/C16-DC | LC-AC | 1.9 | 0.1788 | 4.6 | 0.4159 |
| C20:4 | LC-AC | 2.9 | 0.0293* | 2.4 | 0.0883 |
| C20 | VLC-AC | 3.2 | 0.1964 | 24.6 | 0.4088 |
| C18:1-DC | VLC-AC | 3.3 | 0.0861 | 9.9 | 0.3591 |
| C20-OH/C18-DC | VLC-AC | 2.8 | 0.1026 | 7.0 | 0.2104 |
| C22 | VLC-AC | 1.3 | 0.5074 | 15.7 | 0.4142 |
| Amino acid & fatty acid derivatives | |||||
| C4/Ci4 | SC-AC | 5.9 | 0.1180 | 3.7 | 0.0602 |
| C4-OH | SC-AC | 2.9 | 0.0676 | 3.4 | 0.0193* |
| C4-DC/Ci4-DC | SC-AC | 1.0 | 0.9681 | 1.2 | 0.7348 |