Articles

Metformin inhibits urothelial tumorigenesis in the UPII-mutant Ha-ras transgenic mouse model

Authors: Zhongbo Liu, Noriko Yokoyama, Michael Pollak and Xiaolin Zi

Metabolic reprogramming by KSHV in cellular transformation

Authors: Ying Zhu, Suzane Ramos da Silva and Shou-Jiang Gao

Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton

Authors: Hai Hu, Ashish Juvekar, Costas Lyssiotis, John G Albeck, Dean R Tolan, John M Asara, Gerburg M Wulf and Lewis C Cantley

Metformin down-regulates epithelial-mesenchymal transition (EMT) in fibroblasts from burned patients

Authors: Michael Wetzel, David Herndon and Celeste Finnerty

Short treatment of metformin attenuated insulin resistance and hepatic steatosis in obese mice by mechanisms independents of PPAR-alpha

Authors: Alexandre Teixeira, Camila Souza, Edson Lima, Helena Batatinha and José Rosa Neto

Catechin-rich green tea extract increases the expression of genes of the cholesterol synthetic pathways in livers of normal diet- and high-fat diet-fed rats

Authors: Toshikazu Suzuki, Mayumi Nagata and Ayumi Takagi

A role for central carbon metabolism in mammalian embryonic development?

Authors: Marteinn Snaebjornsson, Nicole Prior, Vinay Bulusu, Bernd Simon, Teresa Carlomagno and Alexander Aulehla

Identifying metabolomic features that predict metastasis of melanoma from a primary site

Authors: Xiaolei Shi, Zeping Hu, Elena Piskounova, Michalis Agathocleous, Sean Morrison and Ralph DeBerardinis

Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes

Authors: Susanne Schuster, Melanie Penke, Theresa Gorski, Anja Barnikol-Oettler, Rolf Gebhardt, Wieland Kiess and Antje Garten

Troglitazone suppresses tumor cell growth and glutamine metabolism through a PPAR-independent mechanism

Authors: Miriam Reynolds and Brian Clem

Metabolic biomarkers for the differential diagnosis of pancreatic ductal adenocarcinoma vs. chronic pancreatitis

Authors: Julia Mayerle, Holger Kalthoff, Regina C Reszka, Beate Kamlage, Erik Peter, Bodo Schniewind, Sandra González-Maldonado, Volker Liebenberg, Christian Pilarsky, Philipp Schatz, Jonas A Schreiber, Ulrich F Weiss and Robert Grützmann

Mitochondrial complex I modulation targets metabolic plasticity in breast cancer cells

Authors: V Krishnan Ramanujan, Qijin Xu and Eva Biener-Ramanujan

Investigating the role of inorganic phosphate in tumor metabolism and metastasis

Authors: Cesar Perez Ramirez and Dorothea Fiedler

Extracellular lactate cooperates with limited glucose and glutamine to sustain breast cancer cell survival by providing ATP, NADPH, amino acids, and glutathione

Authors: Jennifer Molina, Pietro Morlacchi, Leslie Silva, Jennifer Dennison and Gordon Mills

Associations between diet, gut microbiota and markers of CRC risk

Authors: Tyler Culpepper, Maria Ukhanova, Xiaoyu Wang, Yijun Sun and Volker Mai

A metabolic signature of colon cancer initiating cells

Authors: Christelle Johnson, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale and Xiling Shen

Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?

Authors: Eugene J Fine, C Segal-Isaacson, Silvia Herzkopf, Joseph Sparano, Maria Romano, Richard Feinman, Nora Tomuta, Amanda Bontempo and Abdissa Negassa

PI 3-kinase and disease

Authors: Lewis C Cantley

Reductive carboxylation mediated oxidative stress defense supports anchorage independent cell growth

Authors: Lei Jiang, Matthew Mitsche, Ralph Deberardinis and Karine Smans

Mechanisms and consequences of hepatic regulation of mTORC1 by metformin

Authors: Jessica J Howell, Kristina Hellberg, Reuben J Shaw and Brendan D Manning

Energy balance at the organism and cellular level: effects of biguanides

Authors: Michael Pollak

Radiation-induction of MMPs limited the NK-mediated anticancer immunity in lung cancer cells

Authors: Woong Heo, Young Shin Lee, Cheol Hun Son, Kwang Mo Yang, You Soo Park and Jae Ho Bae

Influence of polyphenol-rich apple pomace extract on oxidative damage to DNA in type 2 diabetes mellitus individuals

Authors: Annemarie Grindel, Elisabeth Müllner, Helmut Brath, Walther Jäger, Trine Henriksen, Henrik Enghusen Poulsen, Doris Marko and Karl-Heinz Wagner

Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration

Authors: Béatrice Dirat, Isabelle Ader, Muriel Golzio, Amel Mettouchi, Kathiane Laurent, Frédéric Larbret, Bernard Malavaud, Mireille Cormont, Emmanuel Lemichez, Jean François Tanti and Frédéric Bost

Chemosensitization of leukemia cells through inhibition of NAMPT

Authors: Theresa Gorski, Stefanie Petzold-Quinque, Susanne Schuster, Melanie Penke, Sandy Richter, Wieland Kiess and Antje Garten

The high colon cancer risk in African Americans can be reduced by dietary modification

Authors: Stephen O’Keefe

Regulation of growth and metabolism

Authors: David M Sabatini

Investigation of the role of Ras and other signaling kinases on the regulation of pyruvate dehydrogenase complex activity

Authors: Antonio Garcia-Trinidad, Nicky Whalley and Susan Critchlow

Loss of SIRT3 leads to a compensatory shift in cellular metabolism promoting cancer cell growth

Authors: Eoin McDonnell, Olga R Ilkayeva, Robert D Stevens, Michael J Muehlbauer, James R Bain, Tomas C Becker and Matthew D Hirschey

Altered cancer cell metabolism and cachexia: Calculating the energetic cost of cancer

Authors: Douglas Friesen, Vickie Baracos and Jack Tuszynski

AMPK – roles in nutrient sensing and in cancer

Authors: D Grahame Hardie

Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1

Authors: Katherine Cook, Pamela Clarke, Anni Warri and Robert Clarke

The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism

Authors: John Schell, Kristofor Olson and Jared Rutter

Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib

Authors: Sucheta Telang, Julie O’Neal, Gilles Tapolsky, Brian Clem, Alan Kerr, Yoannis Imbert-Ferndandez and Jason Chesney

Biochemical and biophysical characterization of pyruvate kinase M2 activation by L-serine

Authors: Barbara Chaneton, Finn Holding, Adam Hold, Jiska Van Der Reest, Gabriele Marciano, Marc O’Reilly and Eyal Gottlieb

Antagonistic effects of MYC and hypoxia in channeling glucose and glutamine into de novo nucleotide biosynthesis

Authors: Teresa Fan, Anne Le, Zachary Stine, Ye Yang, Karen Zeller, Weiqiang Zhou, Hongkai Ji, Richard Higashi, Chi Dang and Andrew Lane

Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo

Authors: Melissa Rooke, Lucy A Coupland, Thy Truong and Anneke C Blackburn

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress

Authors: Zachary Schug, Barrie Peck, Dylan Jones, Qifeng Zhang, Israt Alam, Tim Witney, Elizabeth Smethurst, Shaun Grosskurth, Adrian Harris, Susan Critchlow, Eric Aboagye, Michael Wakelam, Almut Schulze and Eyal Gottlieb

Profiling metabolic changes in breast cancer with targeted proteomics

Authors: Stephan Bernhardt, Devina Mitra, Zita Soons, Rainer König, Martina Vetter, Christoph Thomssen, Eva Kantelhardt, Stefan Wiemann and Ulrike Korf

A hypothetical means of treating or preventing cancer

Authors: Steven L McKnight

Adipose tissue homeostasis is deeply disrupted by doxorubicin treatment

Authors: Helena Batatinha, Camila Souza, Edson Lima, Maria Isabel Alonso-Vale, Maysa Cruz, Roberta Da Cunha, Fabio Lira and Jose Rosa

Fructose-2,6-bisphosphate links glucose to survival and growth

Authors: Abdullah Yalcin, Yoannis Imbert-Fernandez, Amy Clem, Julie O’Neal, Sucheta Telang, Brian Clem and Jason Chesney

A metabolic map of hematopoietic stem cells

Authors: Michalis Agathocleous, Zeping Hu and Sean Morrison

Metabolic heterogeneity in cancer

Authors: Ralph J DeBerardinis

Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice

The risk of pancreatic cancer, the 4th deadliest cancer for both men and women in the United States, is increased by obesity. Calorie restriction (CR) is a well-known dietary regimen that prevents or reverses ...

Authors: Kristyn A Liu, Laura M Lashinger, Audrey J Rasmussen and Stephen D Hursting

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growi...

Authors: Shawn D Stuart, Alexandra Schauble, Sunita Gupta, Adam D Kennedy, Brian R Keppler, Paul M Bingham and Zuzana Zachar

Q&A: Targeting metabolism to diagnose and treat cancer

Authors: Ralph J DeBerardinis

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pat...

Authors: Norma Masson and Peter J Ratcliffe

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from f...

Authors: Alden C Klarer, Julie O’Neal, Yoannis Imbert-Fernandez, Amy Clem, Steve R Ellis, Jennifer Clark, Brian Clem, Jason Chesney and Sucheta Telang

TIGAR, TIGAR, burning bright

Cancers cells shift their metabolism towards glycolysis in order to help them support the biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and avoid excessive reactive o...

Authors: Pearl Lee, Karen H Vousden and Eric C Cheung